RAPID MIXER GRANULATOR PDF

Ankur Choudhary Print Question Forum 9 comments Rapid mixer granulator is widely used equipment in pharmaceutical manufacturing. It is used to mix the pharmaceutical ingredients and make the granules before compression and also called a high shear mixer. Impellers and chopper are mainly responsible for wet granulation in the rapid mixer granulator. It has two full length and two half-length blades. These impellers are designed in such a way that small blades lift the material and full-length blades push the material to mix well.

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Mixing chambers Mixing Chambers in Rapid mixer granulator is of 3 types Conical shaped , Domed shape , and Circular shaped although the basic aim behind all the shapes is to eliminate the dead points and wall adhesion i. Filter assembly is on the top of port in this vent air filter is placed which allows the purging air to leave the Mixing chamber and retains the granules inside. Purging air air coming from gasket present below the impeller at an pressure of kg and prevents the mixing of granules with lubrication of impeller thus preventing contamination.

Impeller the Science behind The speed of Impeller should be high enough to cause Roping flow motion as slow speed causes Bumping motion of powder and leads to Inefficient mixing. Bumping motion and Roping motion At higher speed of Impeller size of granules increases and if high speed is for longer time due to continuous collisions between the particles the size of granules will decrease.

The gap between base of mixing chamber is around 2. Chopper the Science behind The use of chopper should not be done always as we know the chopper will break the granules. Firstly look weather active is free flowing or cohesive , weather it lumps or not.

Chopper should be used if active is cohesive or forms lumps at the minimum speed after solution addition. End point Ampere load on Impeller and Chopper i. Ampere load is high in beginning when granulation starts as motors need more power and decreases as end point is reached. End point could also be determined by ensuring the Vortex formation Generally done by Research and Development personnel during Optimization of batch. Fill level in RMG All Mixing chambers have minimum and maximum Fill depth depends upon size of vessel and powder characteristics Before determining depth of fill points to be considered are Rapid mixer granulator How much powder to be granulated is active.

Does the powder Densify or Swell on solvent addition and to what extent Is material constant Is Dip tube length Solution entry tube lesser than the height of powder. Quantity of liquid binder more the concentration of binder better the granules but batch could become unstable after certain limit.

Viscosity of binder is also an critical operating parameter higher the viscosity of binder larger and denser the granules.

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Rapid Mixer Granulator (RMG)

The entire operation is fully dust-free and automatic including discharge. All parts coming in contact with mix are of stainless steel quality and are highly polished. In case of flame proof construction, the control panel should be located in low risk area. Machine is supplied with staircase made from SS pipe and SS embossed sheet for anti silp property.

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Working and principle of Rapid Mixer Granulator (RMG)

Mixing chambers Mixing Chambers in Rapid mixer granulator is of 3 types Conical shaped , Domed shape , and Circular shaped although the basic aim behind all the shapes is to eliminate the dead points and wall adhesion i. Filter assembly is on the top of port in this vent air filter is placed which allows the purging air to leave the Mixing chamber and retains the granules inside. Purging air air coming from gasket present below the impeller at an pressure of kg and prevents the mixing of granules with lubrication of impeller thus preventing contamination. Impeller the Science behind The speed of Impeller should be high enough to cause Roping flow motion as slow speed causes Bumping motion of powder and leads to Inefficient mixing. Bumping motion and Roping motion At higher speed of Impeller size of granules increases and if high speed is for longer time due to continuous collisions between the particles the size of granules will decrease. The gap between base of mixing chamber is around 2.

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