Akigore The clinician should continue to bpl BP and adjust the treatment regimen until goal BP is reached. Secondary outcomes suggest ascog possible reduction in cardiovascular morbidity and mortality using asco and perindopril, although this may be ascribed to differences in blood pressure between the two study arms. On the basis of previous trial evidence, these effects might not be entirely explained by better control of blood pressure, and this issue is addressed in the accompanying article. This is to be expected due to the peripheral vasodilation effects of Amlodipine and Perindopril compared to Atenolol and Bendroflumethiazide. Accept No thanks Read more.
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The ASCOT researchers said that the blood pressure by itself can only explain 15 to 35 of the positive outcomes in the amlodepine arm. We must consider whether the much-used regimen of beta-blockers followed by thiazides is the automatic choice for our patients.
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ASCOT BPLA PDF
ACP J Club. Evid Based Med. Republished in Curr Hypertens Rep. For a given reduction in blood pressure, some suggested that newer agents would confer advantages over diuretics and beta blockers.
ASCOT TRIAL - PowerPoint PPT Presentation